Water → HCID 70874027, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 5-chloro-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl(1,4-dioxaspiro[4.5]decan-8-yl)amino)-2-methylbenzamide (2.0 g, 4.1 mmol) in acetone: water (14 mL+6 mL) was added PTSA (3.1 g, 16 mmol). The resulting reaction mixture was stirred at 70° C. overnight. On completion, the solvent was removed under reduced pressure and the residue was basified with aqueous sodium bicarbonate. The aqueous phase was extracted with ethyl acetate. The combined organic layers were washed with water, dried, concentrated under reduced pressure to give the title compound (1.5 g, 83%) which was used directly in the next step.

Provenance & Evidence