4-Ethyl-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile → 3-(aminomethyl)-4-ethyl-6-methylpyridin-2(1H)-one

Participants

Reaction Steps

To a solution of 4-ethyl-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile (1 eq) in methanol and aq. ammonia solution (9:1) was added a catalytic amount of Raney Nickel. The reaction mixture was stirred at room temperature under hydrogen pressure (balloon pressure) for 2-5 h. On completion of reaction, it was filtered through a celite bed and the filtrate was concentrated under reduced pressure to afford the title compound.

Provenance & Evidence