Ethyl Acetate → HCID 70873766, compound

Participants

Reaction Conditions

Reaction Steps

To stirred solution of 5-hydroxy-2-methyl-3-nitrobenzoate (1.5 g, 7.1 mmol) in ACN (15 mL) were added cesium carbonate (4.64 g, 14.2 mmol) and tert-butyl 3-iodoazetidine-1-carboxylate (3.0 g, 11 mmol). The resulting mixture was heated at 80° C. overnight. On completion, the reaction mixture was diluted with water and extraction was carried out using ethyl acetate. The combined organic layers were washed with water, dried and concentrated under reduced pressure. The crude material was purified by column chromatography to afford the title compound (1.2 g, 46%).

Provenance & Evidence