反应详情

温度

23 °C

To a stirred solution of 5-chloro-3-[ethyl(1-methylpiperidin-4-yl)amino]-2-methylbenzoic acid (crude material, ˜0.7 mmol) and 3-(aminomethyl)-6-methyl-4-(trifluoromethyl)-1,2-dihydropyridin-2-one hydrochloride HCl salt (200 mg, 0.91 mmol) in DMSO (5.3 mL) was added PyBOP (550 mg, 1.05 mmol) and hunig base (366 ul, 2.10 mmol). The reaction mixture was stirred at 23° C. for 7 hours. The reaction mixture was quenched with water and diluted with ethylacetate. The aqueous layer was extracted with dichloromethane. The combined organic layer was washed with brine, dried over Na2SO4, filtered and concentrated. The residue was purified by silica gel column chromatography (SiO2 Ethylacetate/MeOH=10/1+5% triethylamine). The crude compound was triturated with ethylacetate/hexane, and dried to give the titled compound as a white solid (145 mg, 42% yield). 1H-NMR (400 MHz, CDCl3) δppm; 7.08 (d, J=2.4 Hz, 1H), 7.03 (d, J=2.4 Hz, 1H), 6.81-6.85 (m, 1H), 6.35 (s, 1H), 4.71 (d, J=5.2 Hz, 2H), 3.03 (q, J=6.8 Hz, 2H), 2.81-2.85 (m, 2H), 2.68-2.72 (m, 1H), 2.39 (s, 3H), 2.27 (s, 3H), 2.24 (s, 3H), 1.88-1.94 (m, 2H), 1.67-1.72 (m, 4H), 0.85 (t, J=6.8 Hz, 3H); MS (ES) [M+H] 499.1, [M+Na] 521.1; HPLC 96.0% purity.

1. customThe reaction mixture was quenched with water
2. additiondiluted with ethylacetate
3. extractionThe aqueous layer was extracted with dichloromethane
4. washThe combined organic layer was washed with brine
5. dry with materialdried over Na2SO4
6. filtrationfiltered
7. concentrationconcentrated
8. customThe residue was purified by silica gel column chromatography (SiO2 Ethylacetate/MeOH=10/1+5% triethylamine)
9. customThe crude compound was triturated with ethylacetate/hexane
10. customdried