反应详情

温度

55 °C

To a solution of (4R)-1-((R)-1-(4-methoxyphenyl)ethyl)-4-(oxiran-2-yl)pyrrolidin-2-one 1.13 (150 mg, 0.57 mmol) in MeOH (5 mL) was added NaOMe (125 mg, 25% in MeOH), and the solution was heated at 55° C. for 3 hours. The reaction was concentrated and purified by flash chromatography (EtOAc→10% MeOH in EtOAC) to afford the product as a mixture of diastereomers. The isolated mixture was purified by RP-HPLC (C18 Gemini Column) to afford the later eluting diastereomer, which was assigned as (R)-4-((S)-1-hydroxy-2-methoxyethyl)-1-((R)-1-(4-methoxyphenyl)ethyl)pyrrolidin-2-one 1.15.

1. concentrationThe reaction was concentrated
2. custompurified by flash chromatography (EtOAc→10% MeOH in EtOAC)
3. customto afford the product
4. additionas a mixture of diastereomers
5. customThe isolated mixture was purified by RP-HPLC (C18 Gemini Column)
6. customto afford the later eluting diastereomer, which