HCID 117843163, compound → HCID 117843375, compound

HRID 2209061Notes

Reaction equation

ClC1N=C(O[C@@H]([C@H]2CNC(=O)C2)C)C2N(C(C)C)C=NC=2C=1.[CH3:23][O:24][C:25]1[CH:26]=[C:27]([C:33]2[N:38]=[C:37]([O:39][C@@H:40]([CH:42]3[CH2:46][NH:45][C:44](=[O:47])[CH2:43]3)[CH3:41])[C:36]3[N:48]([CH:51]([CH3:53])[CH3:52])[CH:49]=[N:50][C:35]=3[CH:34]=2)[CH:28]=[CH:29][C:30]=1[O:31][CH3:32]>>[CH3:23][O:24][C:25]1[CH:26]=[C:27]([C:33]2[N:38]=[C:37]([O:39][C@@H:40]([C@H:42]3[CH2:46][NH:45][C:44](=[O:47])[CH2:43]3)[CH3:41])[C:36]3[N:48]([CH:51]([CH3:53])[CH3:52])[CH:49]=[N:50][C:35]=3[CH:34]=2)[CH:28]=[CH:29][C:30]=1[O:31][CH3:32]

Participants

Reactant 2

HCID 117843163HCID 117843163, compound

HCID 117843377HCID 117843377, compound

Product 1

HCID 117843375HCID 117843375, compound

Procedure

Following the procedure of Example 3.08, beginning with (R)-4-((R)-1-(6-chloro-3-isopropyl-3H-imidazo[4,5-c]pyridin-4-yloxy)ethyl)pyrrolidin-2-one 2.23 (52 mg crude), R)-4-((R)-1-(6-(3,4-dimethoxyphenyl)-3-isopropyl-3H-imidazo[4,5-c]pyridin-4-yloxy)ethyl)pyrrolidin-2-one 3.07 was synthesized.

Workup

customwas synthesized

Sources & evidence

ORD record: ord-f9b6fe65d3294870b0c41fa3e2bef2a0
Source dataset: uspto-grants-2016_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09376441B2

Reaction notes

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