反应详情

温度

130 °C

2-amino-4-bromobenzoic acid (825 mg, 3.82 mmol) was taken up in acetic anhydride (5.2 mL, 55.01 mmol) and mixture was heated at 130° C. After 4 hours, reaction mixture was cooled to rt and left there for two hours. The solid that precipitated was filtered and washed with cold ether, and dried in-vacuo to yield 7-bromo-2-methyl-4H-benzo[d][1,3]oxazin-4-one 7.25 (451 mg), which was used in the next step without further purification.

1. customreaction mixture
2. temperaturewas cooled to rt
3. waitleft there for two hours
4. customThe solid that precipitated
5. filtrationwas filtered
6. washwashed with cold ether
7. customdried in-vacuo