HuagongsheHuagongshe Chemistry Print Report · For research reference only
7-bromo-4,4-dimethyl-1H-benzo[d][1,3]oxazin-2(4H)-one → 4,4-dimethyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-3,1-benzoxazin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7-bromo-4,4-dimethyl-1H-benzo[d][1,3]oxazin-2(4H)-one | HCID 46856486 | — |
| Reactant | tert-Butyl 2-oxo-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)spiro[indoline-3,4'-piperidine]-1'-carboxylate | HCID 92133768 | — |
| Product | 4,4-dimethyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-3,1-benzoxazin-2-one | HCID 124016192 | — |
Reaction Steps
Following the procedure described for intermediate 7.33 (Step 2), starting from 7-bromo-4,4-dimethyl-1H-benzo[d][1,3]oxazin-2(4H)-one 7.37 (60 mg), 77 mg of 4,4-dimethyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d][1,3]oxazin-2 (4H)-one 7.39 was obtained. LCMS [M+H]+: 304.19.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09376441B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-501a2c78f1e348fb9701daef0a042232 |
| Source note | uspto-grants-2016_06 |