HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 7-Bromo-1,4,4-trimethyl-3,4-dihydroquinolin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 7-Bromo-4,4-dimethyl-3,4-dihydroquinolin-2(1H)-one | HCID 19963707 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 7-Bromo-1,4,4-trimethyl-3,4-dihydroquinolin-2(1H)-one | HCID 19935516 | — |
Reaction Steps
7-bromo-4,4-dimethyl-3,4-dihydroquinolin-2(1H)-one (210 mg, 0.83 mmol) and K2CO3 (335 mg, 2.42 mmol) were taken up in DMF (5 mL). Iodomethane (0.15 mL, 2.4 mmol) was added and the resulting mixture was stirred for 18 h. Water was added, and the resulting solids were filtered and washed with additional water to provide crude 7-bromo-1,4,4-trimethyl-3,4-dihydroquinolin-2(1H)-one that was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09376441B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-219c66806e1645749a020632c3461177 |
| Source note | uspto-grants-2016_06 |