Potassium Carbonate → HCID 117843048, compound

Participants

Reaction Steps

To a mixture of 5-chloro-2-iodophenol (1.21 g, 4.76 mmol) and K2CO3 (723 mg, 5.23 mmol) in acetone (20 mL) was added 3-bromo-2-methyl-propene (0.53 ml, 5.23 mmol), and the reaction was heated to reflux for 16 hours. The reaction was cooled, diluted with EtOAc and water, and the layers were separated. The aqueous layer was extracted with EtOAc (2×) and the combined organics were dried over MgSO4, filtered and concentrated to afford 4-chloro-1-iodo-2-((2-methylallyl)oxy)benzene which was used directly in the next step without further purification.

Provenance & Evidence