2-Mercaptoethanol → HCID 86730811, compound

Participants

Reaction Conditions

Reaction Steps

Into a 200 mL three-necked flask, 2-hydroxyethyl methacrylate (6.51 g, 0.050 mol) as the monomer having a hydroxy group, N,N-dimethylacrylamide (2.48 g, 0.025 mol) as the monomer having an amide group, acrylic acid (1.80 g, 0.025 mol) as the acidic monomer, dimethylsulfoxide (43.2 g) as a solvent, a polymerization initiator VA-061 (Wako Pure Chemical Industries, Ltd., 0.016 g, 0.062 mmol), and 2-mercaptoethanol (2-ME, 43 μL, 0.62 mmol) were added, and the three-necked flask was equipped with a three-way cock, a reflux condenser, a thermometer, and a mechanical stirrer. A monomer concentration was 20% by mass. After inside of the three-necked flask was degassed with a vacuum pump and argon replacement was carried out for 3 times, the mixture was stirred at 60° C. for 0.5 hours, and thereafter, the temperature was raised to 70° C. and the mixture was stirred for 4.5 hours. After completion of the polymerization, the polymerization reaction liquid was cooled to room temperature and the liquid was poured to 500 mL of ethyl acetate and the obtained mixture was left to stand for one night. In the next day, a supernatant liquid was removed by decantation. The obtained solid content was washed 10 times with methanol/n-hexane=5 mL/50 mL. The solid content was dried at 60° C. for one night with a vacuum drier. After liquid nitrogen was poured to the solid content and the solid content was fragmentized with a spatula, the solid content was dried at 60° C. for 3 hours with a vacuum drier. Molecular weights of thus obtained copolymer were a Mn of 17 kD and a Mw of 33 kD (Mw/Mn=1.98).

Provenance & Evidence