HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → HCID 19380596, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | (3,5-Difluorophenyl)boronic acid | HCID 2734338 | — |
| Reactant | 2-Chloro-5-(2,6-difluoro-4-pentylphenyl)pyrimidine | HCID 19380608 | — |
| Catalyst | Tetrakis(triphenylphosphine)palladium | HCID 11979704 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 19380596 | HCID 19380596 | — |
Reaction Steps
A mixture of 77 mmol of 1A, 92 mmol of 3,5-difluorophenylboronic acid (prepared from 3,5-difluorobromobenzene by reaction with magnesium and trimethyl borate), 200 ml of toluene, 92 ml of ethanol, 2.4 g of tetrakis[triphenylphosphine]palladium(0) and 125 ml of a 2 molar aqueous sodium carbonate solution is heated at the boil for 16 hours. Customary work-up gives the product, which can be processed further without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05454975 |
| Source dataset | uspto-grants-1995_10 |
| ORD ID | ord-5cf726f1a1834c3dab461aaf984cf3d8 |
| Source note | uspto-grants-1995_10 |