Ethanol → HCID 15218978, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 44 mmol of 1B and 80 ml of THF is added dropwise at -78° C. to a solution of 48 mmol of lithium diisopropylamide in hexane. The mixture is stirred at -50° C. for 2 hours and then re-cooled to -78° C., and a mixture of 48 mmol of p-toluenesulphonyl cyanide in 20 ml of THF is slowly added dropwise. After warming to room temperature and conventional work-up, the pure product is obtained by recrystallization from ethanol. C 85 N (75) I, Δε=71.3, Δn=0.232 (extrapolated from ZLI-4792)

Provenance & Evidence