(3,5-Difluorophenyl)boronic acid → 2-(3,5-Difluorophenyl)-5-pentylpyrimidine

HRID 2209403Notes

Reaction equation

HRID 2209403 reaction equation
[F:1][C:2]1[CH:3]=[C:4](B(O)O)[CH:5]=[C:6]([F:8])[CH:7]=1.[CH2:12]([C:17]1[CH:18]=[N:19][C:20](Cl)=[N:21][CH:22]=1)[CH2:13][CH2:14][CH2:15][CH3:16]>>[F:1][C:2]1[CH:3]=[C:4]([C:20]2[N:19]=[CH:18][C:17]([CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])=[CH:22][N:21]=2)[CH:5]=[C:6]([F:8])[CH:7]=1

Participants

3

Reactant 2

HCID 2734338(3,5-Difluorophenyl)boronic acidHCID 167565262-Chloro-5-pentylpyrimidine

Product 1

HCID 183482702-(3,5-Difluorophenyl)-5-pentylpyrimidine

Procedure

80 mmol of 3,5-difluorophenylboronic acid are coupled to 80 mmol of 5-pentyl-2-chloropyrimidine analogously to Example IB

Sources & evidence

ORD record
ord-18c80c818ed34bfaaa523bd573d00a6d
Source dataset
uspto-grants-1995_10
Patent number
US05454975

Reaction notes

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