5-Bromo-2-chloropyrimidine → HCID 19380601, compound

HRID 2209405Notes

Reaction equation

HRID 2209405 reaction equation
[CH2:1]([C:4]1[CH:9]=[C:8]([F:10])[C:7]([C:11]2[CH:16]=[C:15]([F:17])[C:14](B(O)O)=[C:13]([F:21])[CH:12]=2)=[C:6]([F:22])[CH:5]=1)[CH2:2][CH3:3].[Cl:23][C:24]1[N:29]=[CH:28][C:27](Br)=[CH:26][N:25]=1>>[CH2:1]([C:4]1[CH:9]=[C:8]([F:10])[C:7]([C:11]2[CH:16]=[C:15]([F:17])[C:14]([C:27]3[CH:26]=[N:25][C:24]([Cl:23])=[N:29][CH:28]=3)=[C:13]([F:21])[CH:12]=2)=[C:6]([F:22])[CH:5]=1)[CH2:2][CH3:3]

Participants

3

Reactant 2

HCID 6066655-Bromo-2-chloropyrimidineHCID 19380606HCID 19380606, compound

Product 1

HCID 19380601HCID 19380601, compound

Procedure

0.25 mol of 39A is coupled to 0.29 mol of 2-chloro-5-bromopyrimidine analogously to Example 1A. The product obtained in this way is processed further without purification.

Workup

  1. customThe product obtained in this way
  2. customis processed further without purification

Sources & evidence

ORD record
ord-412fa076b82c45d2af220d597e30be58
Source dataset
uspto-grants-1995_10
Patent number
US05454975

Reaction notes

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