反应详情

3-acetyl-7-diethylaminocoumarin (1.04 g, prepared according to the procedure described in U.S. Pat. No. 4,147,552), 1.20 g N-(2-piperidinoethyl)-N-ethyl-4-aminobenzaldehyde, 0.10 g piperidinium acetate, and 40 ml toluene were placed in a 100 ml round-bottomed flask fitted with a Dean-Stark trap and condenser. The solution was refluxed for 16 hr with removal of collected water. The toluene was evaporated under reduced pressure and a mixture of 20 ml water and 5 ml ethanol was added to the resultant viscous material. Upon stirring a solid precipitated which was isolated by filtration and drying to give 1.5 g of 7-diethylamino-3-(3-(N-ethyl-N-(2-piperidinoethyl)-4-aminophenyl)propenoyl)coumarin (4) as a red solid; λmax (ethanol)=475 nm. ##STR10##

1. customfitted with a Dean-Stark trap and condenser
2. customThe toluene was evaporated under reduced pressure
3. additiona mixture of 20 ml water and 5 ml ethanol
4. additionwas added to the resultant viscous material
5. customprecipitated which
6. customwas isolated by filtration
7. customdrying