Pyridine → 3-(2-Bromophenyl)-6-(2,6-difluorophenyl)-1,2,4,5-tetrazine

Participants

Reaction Steps

0.94 g (1.05 equivalent) of 2,6-difluorobenzoyl chloride is added dropwise to a mixture containing 1.1 g of (2-bromobenzoyl)hydrazine, 3 ml of dimethylformamide and 0.5 ml of pyridine under cooling. The suspension obtained is stirred at room temperature for 30 minutes, then poured into water. The solid precipitate is separated by filtration and dried to give the desired product as white crystals in a yield of 1.35 g.

Provenance & Evidence