反应详情

Benzo[b]quinolizinium bromide (508.5 g, 1.95 mol) (Bradsher and Parham, J. Org. Chem., 1963, 28, 83-85, Example VIIa) was dissolved in distilled water (5 L) with heating and potassium hexafluorophosphate (367.2 g, 1.95 mol) in water (1.1L) was added in portions. After the addition was complete, the mixture was stirred at ambient temperature for 3 hours, then at 0° C. for 1 hour. The mixture was filtered and washed with cold water to afford 601 g (94.8%) of benzo[b]quinolizinium hexafluorophosphate. (Formula II: R1 =H; X- =PF6-).

1. temperaturewith heating
2. additionAfter the addition
3. waitat 0° C. for 1 hour
4. filtrationThe mixture was filtered
5. washwashed with cold water