HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2209438Generated: November 4, 2026
Methanol → 3-Amino-N-((phenylmethoxy)carbonyl)-L-alanine methyl ester
https://huagongshe.com/reaction/2209438
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Z-Dap-OH | HCID 2756313 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 3-Amino-N-((phenylmethoxy)carbonyl)-L-alanine methyl ester | HCID 11043221 | — |
Reaction Steps
Dissolve Nα -(benzyloxycarbonyl)-β-(amino)-L-alanine (47.6 g, 0.2 mol) in methanol (500 mL) and treat with concentrated sulfuric acid (0.5 mL). Heat to 60° C. for 16 hours, cool and reduce the solvent by 50% in vacuo. Dilute with ethyl ether (500 mL), wash with saturated sodium hydrogen carbonate, then brine. Dry (MgSO4) and evaporate the solvent in vacuo to give Nα -(benzyloxycarbonyl)-β-(amino)-L-alanine, methyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05455242 |
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| Source dataset | uspto-grants-1995_10 |
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| ORD ID | ord-8b48305dec7947a6bf19148843cf1c8c |
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| Source note | uspto-grants-1995_10 |
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