Allylamine → HCID 19380940, compound

Participants

Reaction Steps

To a stirred mixture of allyl amine 25 (2.0 g, 27 mmol), NMM (8.9 mL, 81 mmol), and acetonitrile (140 mL), at ambient temperature was added 4-chlorobutyryl chloride (3.4 mL, 27 mmol). After 20 hours the reaction mixture was concentrated. The residue was dissolved in ethyl acetate and then washed with water, 5% KHSO4 and brine, dried (MgSO4), and concentrated to give 26 (4.1 g, 87%) as a yellow oil. TLC Rf=0.17 (40% ethyl acetate/hexanes).

Provenance & Evidence