1,4-Dioxane hydrochloride → HCID 136346644, compound

HRID 220945Notes

Reaction equation

HRID 220945 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][C:15](=[O:42])[NH:16][CH2:17][C:18]2[CH:23]=[CH:22][C:21]([C:24]([N:26]3[CH2:35][C:34]4[CH:33]=[N:32][N:31]([CH3:36])[C:30]=4[NH:29][C:28]4[CH:37]=[CH:38][CH:39]=[CH:40][C:27]3=4)=[O:25])=[CH:20][C:19]=2[CH3:41])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:43].O1CCOCC1>>[ClH:43].[CH3:41][C:19]1[CH:20]=[C:21]([C:24]([N:26]2[CH2:35][C:34]3[CH:33]=[N:32][N:31]([CH3:36])[C:30]=3[NH:29][C:28]3[CH:37]=[CH:38][CH:39]=[CH:40][C:27]2=3)=[O:25])[CH:22]=[CH:23][C:18]=1[CH2:17][NH:16][C:15](=[O:42])[CH2:14][CH:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 136128381HCID 136128381, compound

Product 1

HCID 136346644HCID 136346644, compoundYield 97%

Procedure

A solution of 4-{[2-methyl-4-(3-methyl-4,10-dihydro-3H-2,3,4,9-tetraaza-benzo[f]azulene-9-carbonyl)-benzylcarbamoyl]-methyl}-piperidine-1-carboxylic acid tert-butyl ester (Compound number 1067) (156 mg, 0.27 mmol) was reacted with 4N HCl/dioxan using an analogous procedure to that described for Example E4.2 to yield the title compound (135 mg, 97%).

Sources & evidence

ORD record
ord-23825b33b8204595afb3365e72000375
Source dataset
uspto-grants-2012_06
Patent number
US08202858B2

Reaction notes

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