2-Bromo-4-methylaniline → 2-(3-Chloro-4-fluorophenyl)-4-methylaniline

HRID 2209468Notes

Reaction equation

HRID 2209468 reaction equation
Br[C:2]1[CH:8]=[C:7]([CH3:9])[CH:6]=[CH:5][C:3]=1[NH2:4].[Cl:10][C:11]1[CH:12]=[C:13](B(O)O)[CH:14]=[CH:15][C:16]=1[F:17]>>[Cl:10][C:11]1[CH:12]=[C:13]([C:2]2[CH:8]=[C:7]([CH3:9])[CH:6]=[CH:5][C:3]=2[NH2:4])[CH:14]=[CH:15][C:16]=1[F:17]

Participants

3

Reactant 2

HCID 114222-Bromo-4-methylanilineHCID 27346603-Chloro-4-fluorophenylboronic Acid (contains varying amounts of Anhydride)

Product 1

HCID 193811842-(3-Chloro-4-fluorophenyl)-4-methylaniline

Procedure

2-bromo-4-methylaniline and 3-chloro-4-fluorobenzene boronic acid were combined to form 2-(3-chloro-4-fluorophenyl)-4-methylaniline,

Sources & evidence

ORD record
ord-de12cc02c47f415995b56ed76769e1e6
Source dataset
uspto-grants-1995_10
Patent number
US05455252

Reaction notes

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