1,4-Dioxane hydrochloride → (4-Aminomethyl-3-fluoro-phenyl)-(3,6-dimethyl-4,10-dihydro-3H-2,3,4,9-tetraaza-benzo[f]azulen-9-yl)-methanone Hydrochloride

HRID 220953Notes

Reaction equation

HRID 220953 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]([N:17]2[CH2:26][C:25]3[CH:24]=[N:23][N:22]([CH3:27])[C:21]=3[NH:20][C:19]3[CH:28]=[C:29]([CH3:32])[CH:30]=[CH:31][C:18]2=3)=[O:16])=[CH:11][C:10]=1[F:33])(C)(C)C.[ClH:35].O1CCOCC1>>[ClH:35].[NH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]([N:17]2[CH2:26][C:25]3[CH:24]=[N:23][N:22]([CH3:27])[C:21]=3[NH:20][C:19]3[CH:28]=[C:29]([CH3:32])[CH:30]=[CH:31][C:18]2=3)=[O:16])=[CH:11][C:10]=1[F:33]

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 136128399[4-(3,6-Dimethyl-4,10-dihydro-3H-2,3,4,9-tetraaza-benzo[f]azulene-9-carbonyl)-2-fluoro-benzyl]-carbamic Acid Tert-butyl Ester

Product 1

HCID 135736009(4-Aminomethyl-3-fluoro-phenyl)-(3,6-dimethyl-4,10-dihydro-3H-2,3,4,9-tetraaza-benzo[f]azulen-9-yl)-methanone HydrochlorideYield 99%

Procedure

[4-(3,6-Dimethyl-4,10-dihydro-3H-2,3,4,9-tetraaza-benzo[f]azulene-9-carbonyl)-2-fluoro-benzyl]-carbamic acid tert-butyl ester from Example E98.1 (1.29 g, 2.8 mmol) was reacted with 4N HCl/dioxan using an analogous procedure to that described for Example E4.2 to yield the title compound (1.1 g, 99%).

Sources & evidence

ORD record
ord-dfae22a595e14693b711da32191c8ff6
Source dataset
uspto-grants-2012_06
Patent number
US08202858B2

Reaction notes

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