2-Chloro-4,6-dimethylpyrimidine → HCID 54473773, compound

Participants

Reaction Steps

Using a procedure similar to that described in Example 86 except starting with 4-amino-1-(9,10-dihydro-9,10-methanoanthracen-9-ylmethyl)piperidine (prepared as described in Example 8b) and 2-chloro-4,6-dimethylpyrimidine the hydrochloride salt of the title compound was obtained as a white solid (55%), mp 205°-207° C.; MS(CI): 411 (M+H); NMR (250 MHz, DMSO-d6): 10.07(br s, 1H), 8.40(br m, 1H), 7.38-7.31(m, 4H), 7.03-6.94(m, 4H), 6.72(s, 1H), 4.46(s, 1H), 4.35-4.33(m, 2H), 4.21-3.97(br m, 1H), 3.60-3.48(m, 4H), 2.74(s, 2H), 2.37(s, 6H), 2.13-1.94(m, 4H).

Provenance & Evidence