HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2209634Generated: November 1, 2026
Trityl chloride → N-trityl-t-butyldimethylsilyloxy serine methyl ester
https://huagongshe.com/reaction/2209634
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trityl chloride | HCID 6456 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | t-Butyldimethylsilyloxyserine methyl ester | HCID 22856314 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-trityl-t-butyldimethylsilyloxy serine methyl ester | HCID 22856313 | — |
Reaction Steps
To t-butyldimethylsilyloxyserine methyl ester (27.5 g; 0.118 mol) dissolved in CH2Cl2 (125 ml) and diisopropylethylamine (25 ml; 0.14 mol) and cooled to 0° C. is added tritylchloride (33. g; 0.118 mol) portionwise over 2 minutes. The reaction is stirred for 4 hours at 25° C., diluted with CH2Cl2 and washed with H2O 3×. The organic phase is dried (MgSO4) and concentrated to dryness to give N-trityl-t-butyldimethylsilyloxy serine methyl ester as a tan solid which is used directly next Step C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05455260 |
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| Source dataset | uspto-grants-1995_10 |
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| ORD ID | ord-20f63b641a6a40509ff4d8af94c81f94 |
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| Source note | uspto-grants-1995_10 |
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