反应详情

A heterogeneous mixture of 4-[[4-methoxybenzenesulfonyl](benzyl)amino]-1-[benzyl]-4-[carbomethoxy]-piperidine (1.2 g, 2.26 mmol) in 50% aqueous sodium hydroxide (10 mL) and methanol (50 mL) is heated to reflux for 16 hours. The methanol is evaporated and the residue is neutralized with 4N hydrochloric acid. The aqueous solution is extracted with ethyl acetate. The combined organic extracts are dried (NaSO4) and the solvent is evaporated to give 4-[[4-methoxybenzenesulfonyl](benzyl)amino]-1-[benzyl]-4-[carboxy]piperidine.

1. temperatureis heated
2. temperatureto reflux for 16 hours
3. customThe methanol is evaporated
4. extractionThe aqueous solution is extracted with ethyl acetate
5. dry with materialThe combined organic extracts are dried (NaSO4)
6. customthe solvent is evaporated