Hydroxyamine hydrochloride → HCID 54386776, compound

Participants

Reaction Conditions

Reaction Steps

A stirred solution of ethyl 2-[5-[5-(4-cyanophenoxy)pentyloxy]-2-[N,N-bis(1-methylethyl)aminocarbonyl]phenoxy]-2-methylpropanoate (1.2 g, 2.3 mmol) in 30 mL of anhydrous ethanol is treated with hydroxylamine hydrochloride (480 mg, 6.8 mmol) and 21% sodium ethoxide solution in ethanol (2.6 mL, 6.8 mmol) and stirred at 50° C. overnight. The reaction is concentrated in vacuo and purified by chromatography on silica gel (20 g) with 80% ethyl acetate/hexane as the eluent to afford ethyl 2-[5-[5-[4-[amino(hydroxyimino)methyl]-phenoxy]pentyloxy]-2-[N,N-bis(1-methylethyl)carbamoyl]phenoxy]-2-methylpropanoate as a colorless foam;

Provenance & Evidence