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HRID220973

反应详情

EQUATION

反应方程式

HRID 220973 的结构方程式

REACTANTS

反应物

2
结构：C1COCCO1.Cl
HCID20443148

1,4-Dioxane hydrochloride

C4H9ClO2

结构：Cn1ncc2c1Nc1cc(Cl)ccc1N(C(=O)c1ccc(CNC(=O)CNC(=O)OC(C)(C)C)c(F)c1)C2
HCID136128360

未命名化合物

PRODUCTS

生成物

1
结构：Cl.Cn1ncc2c1Nc1cc(Cl)ccc1N(C(=O)c1ccc(CNC(=O)CN)c(F)c1)C2
HCID136346650

未命名化合物

收率 83%

PROCEDURE

实验过程

{[4-(6-Chloro-3-methyl-4,10-dihydro-3H-2,3,4,9-tetraaza-benzo[f]azulene-9-carbonyl)-2-fluoro-benzylcarbamoyl]-methyl}-carbamic acid tert-butyl ester from Example E113 (120 mg, 0.22 mmol) was reacted with 4N HCl/dioxan using an analogous procedure to that de-scribed for Example E4.2 to yield the title compound (95 mg, 83%).