1,4-Dioxane hydrochloride → 2-Amino-N-[4-(6-chloro-3-methyl-4,10-dihydro-3H-2,3,4,9-tetraaza-benzo[f]azulene-9-carbonyl)-2-fluoro-benzyl]-acetamide Hydrochloride
Reaction equation
C(OC(=O)[NH:7][CH2:8][C:9](=[O:37])[NH:10][CH2:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]([N:20]2[CH2:29][C:28]3[CH:27]=[N:26][N:25]([CH3:30])[C:24]=3[NH:23][C:22]3[CH:31]=[C:32]([Cl:35])[CH:33]=[CH:34][C:21]2=3)=[O:19])=[CH:14][C:13]=1[F:36])(C)(C)C.Cl.O1CCOCC1>>[ClH:35].[NH2:7][CH2:8][C:9]([NH:10][CH2:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]([N:20]2[CH2:29][C:28]3[CH:27]=[N:26][N:25]([CH3:30])[C:24]=3[NH:23][C:22]3[CH:31]=[C:32]([Cl:35])[CH:33]=[CH:34][C:21]2=3)=[O:19])=[CH:14][C:13]=1[F:36])=[O:37]Participants
3
Reactant 2
Product 1
Procedure
{[4-(6-Chloro-3-methyl-4,10-dihydro-3H-2,3,4,9-tetraaza-benzo[f]azulene-9-carbonyl)-2-fluoro-benzylcarbamoyl]-methyl}-carbamic acid tert-butyl ester from Example E113 (120 mg, 0.22 mmol) was reacted with 4N HCl/dioxan using an analogous procedure to that de-scribed for Example E4.2 to yield the title compound (95 mg, 83%).
Sources & evidence
- ORD record
- ord-fe2ce2083ebc4664b550715517368f43
- Source dataset
- uspto-grants-2012_06
- Patent number
- US08202858B2
Reaction notes
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