Hydroxyamine hydrochloride → HCID 88359135, compound

Participants

Reaction Conditions

Reaction Steps

A stirred solution of 2-[5-[5-(4-cyanophenoxy)pentyloxy]-2-[N,N-bis(1-methylethyl)aminocarbonyl]phenoxy]-2-methylpropionic acid (1.4 g, 2.8 mmol) in 30 mL of anhydrous ethanol is treated with hydroxylamine hydrochloride (590 mg, 8.4 mmol) and 21% sodium ethoxide solution in ethanol (3.1 mL, 5.7 mmol) and stirred at 50° C. overnight. The reaction is concentrated in vacuo and purified by chromatography on silica gel (20 g) with 80-100% ethyl acetate/hexane followed by 0-10% methanol/ethyl acetate as the eluent to afford 2-[5-[5-[4-[amino(hydroxyimino)methyl]phenoxy]pentyloxy]2-[N,N-bis(1-methylethyl) -aminocarbonyl]phenoxy]-2-methylpropanoic acid sodium salt as a colorless foam;

Provenance & Evidence