4-Chlorobenzoyl chloride → HCID 178457691, compound

HRID 2209782Notes

Reaction equation

HRID 2209782 reaction equation
[C:1]([O:5][C:6]([C:8]1[CH:13]=[CH:12][C:11]([C@H:14]2[CH2:19][CH2:18][C@H:17]([NH:20][CH2:21][C:22]#[CH:23])[CH2:16][CH2:15]2)=[C:10]([CH2:24][NH:25][CH3:26])[CH:9]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[Cl:27][C:28]1[CH:36]=[CH:35][C:31]([C:32](Cl)=[O:33])=[CH:30][CH:29]=1>>[C:1]([O:5][C:6]([C:8]1[CH:13]=[CH:12][C:11]([C@H:14]2[CH2:15][CH2:16][C@H:17]([N:20]([C:32](=[O:33])[C:31]3[CH:35]=[CH:36][C:28]([Cl:27])=[CH:29][CH:30]=3)[CH2:21][C:22]#[CH:23])[CH2:18][CH2:19]2)=[C:10]([CH2:24][NH:25][CH3:26])[CH:9]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 85014-Chlorobenzoyl chlorideHCID 178457496HCID 178457496, compound

Product 1

HCID 178457691HCID 178457691, compound

Procedure

from trans-4-(4-tert.butoxycarbonyl-methylaminomethylphenyl)-N-propargylcyclohexylamine and 4-chlorobenzoylchloride. Colourless oil. Rf value: 0.46 (silica gel, petroleum ether/ethyl acetate=2:1, v:v).

Sources & evidence

ORD record
ord-c8f25dc2e098443391b7524685d58844
Source dataset
uspto-grants-1995_10
Patent number
US05455273

Reaction notes

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