Acetyl chloride → HCID 178482890, compound

HRID 2209793Notes

Reaction equation

[CH2:1]([NH:8][C@H:9]1[CH2:14][CH2:13][C@H:12]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])=[CH:17][C:16]=2[CH2:28][NH:29][CH3:30])[CH2:11][CH2:10]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:31](Cl)(=[O:33])[CH3:32]>>[C:31]([N:8]([C@H:9]1[CH2:14][CH2:13][C@H:12]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([O:23][C:24]([CH3:26])([CH3:27])[CH3:25])=[O:22])=[CH:17][C:16]=2[CH2:28][NH:29][CH3:30])[CH2:11][CH2:10]1)[CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)(=[O:33])[CH3:32]

Participants

Reactant 2

HCID 6367Acetyl chloride

HCID 178482889HCID 178482889, compound

Product 1

HCID 178482890HCID 178482890, compound

Procedure

from trans-N-benzyl-4-(4-tert.butoxycarbonyl-methylaminomethylphenyl)cyclohexylamine and acetylchloride. Oil. Rf value: 0.66 (alumina, ethyl acetate/petroleum ether= 1:3, v:v).

Sources & evidence

ORD record: ord-43f37f6b3ddf49a38c42d9ccbc894f15
Source dataset: uspto-grants-1995_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05455273

Reaction notes

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