Acetyl chloride → HCID 178482893, compound

HRID 2209794Notes

Reaction equation

[C:1]([O:5][C:6]([C:8]1[CH:13]=[CH:12][C:11]([C@H:14]2[CH2:19][CH2:18][C@H:17]([NH:20][CH2:21][C:22]3[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=3)[CH2:16][CH2:15]2)=[C:10]([CH2:29][NH:30][CH3:31])[CH:9]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:32](Cl)(=[O:34])[CH3:33]>>[C:32]([N:20]([C@H:17]1[CH2:18][CH2:19][C@H:14]([C:11]2[CH:12]=[CH:13][C:8]([C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:7])=[CH:9][C:10]=2[CH2:29][NH:30][CH3:31])[CH2:15][CH2:16]1)[CH2:21][C:22]1[CH:23]=[CH:24][C:25]([F:28])=[CH:26][CH:27]=1)(=[O:34])[CH3:33]

Participants

Reactant 2

HCID 6367Acetyl chloride

HCID 178482892HCID 178482892, compound

Product 1

HCID 178482893HCID 178482893, compound

Procedure

from trans-4-(4-tert.butoxycarbonyl-methylaminomethylphenyl)-N-(4-fluorobenzyl)-cyclohexylamine and acetylchloride. Colourless oil.

Sources & evidence

ORD record: ord-6943859ddad24cf9ba1bd47d3d991a32
Source dataset: uspto-grants-1995_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05455273

Reaction notes

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