Hydrochloric Acid → HCID 178485424, compound

Participants

Reaction Steps

33.8 g of trans-N-(4-chlorobenzoyl)-N-methyl-4-phenylcyclohexylamine, 24.3 g of paraformaldehyde and 24.3 g of zinc chloride are suspended in 1300 ml of methylene chloride at ambient temperature and over a period of 2.5 hours hydrogen chloride is introduced, whilst the temperature rises to 29° C. The solution obtained is stirred overnight, poured into 1500 ml of ice water and then stirred until phase separation is obtained. The organic phase is washed with water, dried and concentrated by evaporation and the residue is recrystallised from ethyl acetate. 30.1 g of the title compound, melting point 174°-176° C., are obtained.

Provenance & Evidence