HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 178486026, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | HCID 178486025 | HCID 178486025 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 178486026 | HCID 178486026 | — |
Reaction Steps
15.4 g of trans-N-tert.butoxycarbonyl-N-methyl-4-(4-hydroxymethylphenyl)cyclohexylamine in 120 ml of methylene chloride are mixed at O° C. with 4.5 ml of methanesulphonic acid chloride and then 8.1 ml of triethylamine in 20 ml of methylene chloride are slowly added dropwise. After stirring overnight, water is added, the organic phase is washed with water, dried and concentrated by evaporation. After recrystallisation from diisopropylether at low temperature, 12.1 g of the title compound are obtained, melting point 138°-139° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05455273 |
| Source dataset | uspto-grants-1995_10 |
| ORD ID | ord-a2110ef5423a4f52abaa58ab45c9737d |
| Source note | uspto-grants-1995_10 |