HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 178482769, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-(Methylamino)-1-propanol | HCID 10148986 | — |
| Reactant | HCID 178486026 | HCID 178486026 | — |
| Product | HCID 178482769 | HCID 178482769 | — |
Reaction Steps
6.0 g of trans-N-tert.butoxycarbonyl-N-methyl-4-(4-methanesulphonyloxymethylphenyl)cyclohexylamine, 4.2 g of potassium carbonate and 1.6 g of N-methyl-3-hydroxypropylamine are heated together to 50° C. in 50 ml of dimethylformamide overnight. The mixture is poured into water and extracted with ethyl acetate. After drying of the organic phase, removal of the solvent and recrystallisation from petroleum ether, 7.1 g of the title compound are obtained, melting point 63°-65° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05455273 |
| Source dataset | uspto-grants-1995_10 |
| ORD ID | ord-714b90c8e57a4641a07f6291f7a19239 |
| Source note | uspto-grants-1995_10 |