Trifluoroacetic acid → HCID 178482764, compound

Participants

Reaction Steps

7.1 g of trans-N-tert.butoxycarbonyl-N-methyl-4-[4-(3-hydroxypropyl)methylaminomethylphenyl]cyclohexylamine are combined with 20 ml of trifluoroacetic acid in 150 ml of methylene chloride at ambient temperature. After 2 hours, ice and 6N sodium hydroxide solution are added, the organic phase is separated off, washed, dried and evaporated down. After the residue has been recrystallised from ether, 3.1 g of the title compound are obtained, melting point 144°-146° C.

Provenance & Evidence