3-Bromo-1-propanol → HCID 178457687, compound

HRID 2209809Notes

Reaction equation

HRID 2209809 reaction equation
[Cl:1][C:2]1[CH:28]=[CH:27][C:5]([C:6]([N:8]([C@H:12]2[CH2:17][CH2:16][C@H:15](C3C=CC(CNC)=CC=3)[CH2:14][CH2:13]2)[CH2:9][C:10]#[CH:11])=[O:7])=[CH:4][CH:3]=1.Br[CH2:30][CH2:31][CH2:32][OH:33]>C(Cl)Cl.CO>[Cl:1][C:2]1[CH:28]=[CH:27][C:5]([C:6]([N:8]([C@H:12]2[CH2:17][CH2:16][C@H:15]([C:4]3[CH:3]=[CH:2][C:28]([CH2:30][CH2:31][CH2:32][OH:33])=[CH:27][C:5]=3[CH2:6][NH:8][CH3:9])[CH2:14][CH2:13]2)[CH2:9][C:10]#[CH:11])=[O:7])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 123083-Bromo-1-propanolHCID 178457689HCID 178457689, compound

Product 1

HCID 178457687HCID 178457687, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

from trans-N-(4-chlorobenzoyl)-N-propargyl-4-(4-methylaminomethylphenyl)cyclohexylamine and 3-bromo-1-propanol. Oil. Rf value: 0.53 (alumina, methylene chloride/methanol=50:1, v:v).

Sources & evidence

ORD record
ord-8dfb4337eb02470da5a5c7dbb1fa3265
Source dataset
uspto-grants-1995_10
Patent number
US05455273

Reaction notes

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