3-Bromo-1-propanol → HCID 178457688, compound

HRID 2209810Notes

Reaction equation

HRID 2209810 reaction equation
[CH2:1]([N:4]([C@H:14]1[CH2:19][CH2:18][C@H:17](C2C=CC(CNC)=CC=2)[CH2:16][CH2:15]1)[C:5](=[O:13])[C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][CH:7]=1)[CH:2]=[CH2:3].Br[CH2:30][CH2:31][CH2:32][OH:33]>C(Cl)Cl.CO>[CH2:1]([N:4]([C@H:14]1[CH2:15][CH2:16][C@H:17]([C:7]2[CH:8]=[CH:9][C:10]([CH2:30][CH2:31][CH2:32][OH:33])=[CH:11][C:6]=2[CH2:5][NH:4][CH3:1])[CH2:18][CH2:19]1)[C:5](=[O:13])[C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][CH:7]=1)[CH:2]=[CH2:3]

Participants

4

Reactant 2

HCID 123083-Bromo-1-propanolHCID 178457690HCID 178457690, compound

Product 1

HCID 178457688HCID 178457688, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

from trans-N-allyl-N-(4-chlorobenzoyl)-4-(4-methylaminomethylphenyl)cyclohexylamine and 3-bromo-1-propanol. Oil. Rf value: 0.56 (alumina, methylene chloride/methanol=50:1, v:v).

Sources & evidence

ORD record
ord-be3c096ea3e64d14a5fb737773dd8710
Source dataset
uspto-grants-1995_10
Patent number
US05455273

Reaction notes

Loading…