Pivaloyl chloride → HCID 178482779, compound

HRID 2209814Notes

Reaction equation

[Cl:1][C:2]1[CH:30]=[CH:29][C:5]([C:6]([N:8]([C@H:10]2[CH2:15][CH2:14][C@H:13]([C:16]3[CH:21]=[CH:20][C:19]([CH2:22][CH2:23][CH2:24][OH:25])=[CH:18][C:17]=3[CH2:26][NH:27][CH3:28])[CH2:12][CH2:11]2)[CH3:9])=[O:7])=[CH:4][CH:3]=1.[C:31](Cl)(=[O:36])[C:32]([CH3:35])([CH3:34])[CH3:33]>>[Cl:1][C:2]1[CH:30]=[CH:29][C:5]([C:6]([N:8]([C@H:10]2[CH2:11][CH2:12][C@H:13]([C:16]3[CH:21]=[CH:20][C:19]([CH2:22][CH2:23][CH2:24][O:25][C:31](=[O:36])[C:32]([CH3:35])([CH3:34])[CH3:33])=[CH:18][C:17]=3[CH2:26][NH:27][CH3:28])[CH2:14][CH2:15]2)[CH3:9])=[O:7])=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 62493Pivaloyl chloride

HCID 178482766HCID 178482766, compound

Product 1

HCID 178482779HCID 178482779, compound

Procedure

from trans-N-(4-chlorobenzoyl)-N-methyl-4-[4-(3-hydroxypropyl)methylaminomethylphenyl]cyclohexylamine and pivaloylchloride. Melting point 100°-102° C.

Sources & evidence

ORD record: ord-e7ae656facd44d3fabaa289d334edc84
Source dataset: uspto-grants-1995_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05455273

Reaction notes

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