1-Chloro-1-chloromethyl-1-silacyclopentane → HCID 19382012, compound

HRID 2209824Notes

Reaction equation

HRID 2209824 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([Mg]Br)=[CH:4][CH:3]=1.Cl[Si:11]1([CH2:16][Cl:17])[CH2:15][CH2:14][CH2:13][CH2:12]1>>[Cl:17][CH2:16][Si:11]1([C:5]2[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=2)[CH2:15][CH2:14][CH2:13][CH2:12]1

Participants

3

Reactant 2

HCID 193820151-Chloro-1-chloromethyl-1-silacyclopentaneHCID 178418676HCID 178418676, compound

Product 1

HCID 19382012HCID 19382012, compound

Procedure

In the same apparatus and procedures as Example 1 was reacted 62 ml of 4-fluorophenylmagnesiumbromide solution (1.0 M in diethylether) with 1-chloro-1-chloromethyl-1-silacyclopentane prepared from the above procedure i) for 1 hr at 60° C. In the same method as Example 1 was treated the reaction product to give 10.34 g of 1-chloromethyl-1-(4-fluorophenyl)-1-silacyclopentane (b.p. 98° C./0.5 mmHg).

Workup

  1. customprepared from the above procedure i) for 1 hr at 60° C
  2. additionIn the same method as Example 1 was treated the reaction product

Sources & evidence

ORD record
ord-b61fbaf11a5542109866fa18b0495ab6
Source dataset
uspto-grants-1995_10
Patent number
US05455356

Reaction notes

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