1H-1,2,4-Triazole → HCID 19382009, compound

Participants

Reaction Steps

To a 100 ml, round bottomed flask equipped with a condenser and a dropping funnel were added 0.29 g of NaH (0.01 mol, 80% dispersion in mineral oil) and 2 ml of DMF. After resolving 0.78 g (0.011 mol) of 1,2,4-triazole in 2 ml of dried DMF, the solution was added through the dropping funnel and the mixture was stirred for 15 min. 3.00 g (0.009 mol) of 1-iodomethyl-1-(4-ethoxyphenyl)-1-silacyclopentane as prepared in Example 9 was diluted with 3 ml of DMF to be dropwisely added to the flask, and the mixture was stirred at 45° C. for 4 and half hrs. After confirming by GC that all the reactants were participated with the reaction, the aqueous saturated NH4Cl solution was added therein, and the organic material was extracted three times 30 ml of diethylether. The extract was dried on anhydrous MgSO4, and filtered to remove the solvent The residue was separated by silica gel column (eluent: ether) to obtain 2.1 g of 1-(4-ethoxyphenyl)-1-(1H-1,2,4-triazole-1-yl) methyl-1-silacyclopentane.

Provenance & Evidence