Tetrahydrofuran → HCID 19432430, compound

Participants

Reaction Steps

To a mixture of methyl 3-bromo-dibenzofuran 7-carboxylate (3.2 g, 10.5 mmol) in 2:1 THF:methanol (90 ml) was added 2.5N NaOH (60 ml). After stirring at room temperature for 1 hour, the reaction was complete. Nearly all the THF:methanol was evaporated off and then the mixture was adjusted to pH=1 with concentrated HCl and extracted with ethyl acetate. Drying (MgSO4) and evaporation yielded 3.1 g (100%) of the title compoundhich was used in the next reaction without purification.

Provenance & Evidence