Ammonia → HCID 57129286, compound

HRID 2209872Notes

Reaction equation

HRID 2209872 reaction equation
[C:1]([C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:14]=[CH:13][C:12]([O:15][CH2:16][C@H:17]3[NH:21][C:20](=[O:22])[C@H:19]([CH2:23][C:24]([O:26]C)=[O:25])[CH2:18]3)=[CH:11][CH:10]=2)=[N:7][CH:8]=1)#[N:2].N>[Ni].CO>[NH2:2][CH2:1][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:10]=[CH:11][C:12]([O:15][CH2:16][C@H:17]3[NH:21][C:20](=[O:22])[C@H:19]([CH2:23][C:24]([OH:26])=[O:25])[CH2:18]3)=[CH:13][CH:14]=2)=[N:7][CH:8]=1

Participants

5

Reactant 2

HCID 222AmmoniaHCID 57167841HCID 57167841, compound

Product 1

HCID 57129286HCID 57129286, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

Prepared from (3S,5S)-5-[[4-(5-cyano-2-pyridyl)phenyl]oxymethyl]-3-[(methoxycarbonyl)methyl]-2-pyrrolidinone by saponification analogously to Example 13 and subsequent hydrogenation with Raney nickel in methanol/conc. aqueous ammonia.

Sources & evidence

ORD record
ord-4b6d62bb7c404f1d93d25a8062ba9c76
Source dataset
uspto-grants-1995_10
Patent number
US05455348

Reaction notes

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