Hydrogen Bromide → HCID 15290773, compound

Participants

Reaction Steps

4-(4-hydroxybutyl)-2(1H)-quinolinone (1 g, 4.60 mmol) was suspended in 47%hydrobromic acid solution (20 ml) and the mixture was refluxed for 16 hours. The reaction mixture was cooled in ice bath and the separated solid was filtered off by aspiration. The residue was washed with water and recrystallized with methanol (with treatment with activated carbon) to give the entitled compound (II-4) as white crystals (790 mg, yield 61.3%, mp 156°-158 ° C. (methanol)).

Provenance & Evidence