Sodium Bicarbonate → HCID 19379690, compound

Participants

Reaction Steps

A mixture of 4-(2-bromoethyl)-1-methyl-2(1H)-quinolinone (II-7) (500 mg, 1.88 mmol), 3-(4-piperidinyl)-1H-indole (376.5 mg, 1.88 mmol) and sodium hydrogencarbonate (236.9 mg, 2.82 mmol) in dry dimethylformamide 5 ml was allowed to react 90 ° C. for 3.5 hours. The reaction mixture was poured into ice-water and then the separated solid was filtered off by aspiration. The solid was washed with water and dried. The obtained solid was dissolved in developing solvent (chloroform: methanol=95:5) and purified by silica gel column chromatography. After removing first eluted impurity, a colorless solution was collected and the solvent was distilled off to give the desired product (III-17) (536 mg) as white crystals (yield 74.0%, mp 79°-81 ° C. (benzene-hexane)).

Provenance & Evidence