HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → Ethyl 3-(2,4-difluorophenyl)-3-oxopropanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | Diethyl (2,4-difluorobenzoyl)malonate | HCID 15105381 | — |
| Solvent | Water | HCID 962 | — |
| Product | Ethyl 3-(2,4-difluorophenyl)-3-oxopropanoate | HCID 2758338 | — |
Reaction Steps
41.4 g of the crude diethyl (2,4-difluorobenzoyl)malonate in 130 ml of water and 170 mg of p-toluenesulphonic acid are refluxed for 8.5 hours. The mixture is extracted using methylene chloride, and the methylene chloride phase is washed with water, dried over sodium sulphate and concentrated in vacuo.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05457104 |
| Source dataset | uspto-grants-1995_10 |
| ORD ID | ord-004f342da97a46c88ff818f4982d3639 |
| Source note | uspto-grants-1995_10 |