HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 3-Chloro-2,4-difluorobenzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3-Chloro-2,4-difluorobenzoic acid | HCID 2773532 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-Chloro-2,4-difluorobenzoyl chloride | HCID 2773538 | — |
Reaction Steps
Thionyl chloride is metered at 70° C. to a suspension of 235 g (1.22 mol) of 3-chloro-2,4-difluorobenzoic acid in 800 ml of toluene and 3 ml of dimethylformamide until a clear solution has formed and evolution of gas is no longer observed. The toluene and excess thionyl chloride are then distilled off, and the product is subsequently obtained by distillation.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05457104 |
| Source dataset | uspto-grants-1995_10 |
| ORD ID | ord-06788bff09154a40a32b3df082c85d9e |
| Source note | uspto-grants-1995_10 |