HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl (2,6-dichloronicotinoyl)-malonate → Ethyl 3-(2,6-dichloropyridin-3-YL)-3-oxopropanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl (2,6-dichloronicotinoyl)-malonate | HCID 22077288 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | p-Toluenesulfonic acid | HCID 6101 | — |
| Product | Ethyl 3-(2,6-dichloropyridin-3-YL)-3-oxopropanoate | HCID 44140080 | — |
Reaction Steps
The crude diethyl (2,6-dichloronicotinoyl)-malonate is refluxed for 2 hours in 45 ml of water and 90 mg of p-toluenesulphonic acid. The mixture is extracted using methylene chloride, and the methylene chloride phase is washed with water, dried over sodium sulphate and concentrated in vacuo. The crude product is purified on silica gel (eluent dichloromethane).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05457104 |
| Source dataset | uspto-grants-1995_10 |
| ORD ID | ord-96f345fc899f476b8d89da6f2a51e32d |
| Source note | uspto-grants-1995_10 |