HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methoxyacetyl chloride → 6-(2-Methoxyacetamido)-4-(3'-chloroanilino)quinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methoxyacetyl chloride | HCID 96623 | — |
| Reactant | N4-(3-chlorophenyl)quinazoline-4,6-diamine | HCID 11807783 | — |
| Product | 6-(2-Methoxyacetamido)-4-(3'-chloroanilino)quinazoline | HCID 19963150 | 41% |
Reaction Steps
Using an analogous procedure to that described in Example 13 except that the reaction mixture was stirred at ambient temperature rather than being heated to 100° C., 6-amino-4-(3'-chloroanilino)quinazoline was reacted with 2-methoxyacetyl chloride to give 6-(2-methoxyacetamido)-4-(3'-chloroanilino)quinazoline in 41% yield, m.p. 177°-180° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05457105 |
| Source dataset | uspto-grants-1995_10 |
| ORD ID | ord-f944e245a69c4472a611ba8c611c58a8 |
| Source note | uspto-grants-1995_10 |