Acetic Anhydride → 6-Acetamido-4-(3'-trifluoromethylanilino)quinazoline

HRID 2210016Notes

Reaction equation

HRID 2210016 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][N:6]=[C:5]2[NH:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([F:22])([F:21])[F:20])[CH:14]=1.[C:23](OC(=O)C)(=[O:25])[CH3:24]>>[C:23]([NH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][N:6]=[C:5]2[NH:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([F:21])([F:22])[F:20])[CH:14]=1)(=[O:25])[CH3:24]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 53281884-N-[3-(trifluoromethyl)phenyl]quinazoline-4,6-diamine

Product 1

HCID 199632086-Acetamido-4-(3'-trifluoromethylanilino)quinazolineYield 87%

Procedure

Using an analogous procedure to that described in Example 11, 6-amino-4-(3'-trifluoromethylanilino)quinazoline was reacted with acetic anhydride to give 6-acetamido-4-(3'-trifluoromethylanilino)quinazoline in 87% yield as a solid.

Sources & evidence

ORD record
ord-84a3a3bd73e74384946fce95f05951b1
Source dataset
uspto-grants-1995_10
Patent number
US05457105

Reaction notes

Loading…